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More Information Multiple sclerosis care at Mayo Clinic Exercise and multiple sclerosis Is there a multiple sclerosis diet? Mindfulness practice: Can it reduce symptoms of MS? Vitamin D and MS: Any connection? Vitamins for MS: Do supplements make a difference? Show more related information. Share on: Facebook Twitter. Show references What is multiple sclerosis? National Multiple Sclerosis Society.

Accessed Dec. Daroff RB, et al. Multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system. In: Bradley's Neurology in Clinical Practice. Philadelphia, Pa. Ferri FF. Multiple sclerosis. In: Ferri's Clinical Advisor Olek MJ.

Clinical presentation, course, and prognosis of multiple sclerosis in adults. Wingerchuk DM expert opinion. Ciccarelli O. Multiple sclerosis in New therapies and biomarkers. The Lancet. Keegan BM. Therapeutic decision making in a new drug era in multiple sclerosis. Seminars in Neurology. Goldman L, et al. Multiple sclerosis and demyelinating conditions of the central nervous system. In: Goldman-Cecil Medicine.

Lotze TE. Pathogenesis, clinical features, and diagnosis of pediatric multiple sclerosis. Kantarci OH, et al. Novel immunomodulatory approaches for the management of multiple sclerosis.

Disease-modifying treatment of relapsing-remitting multiple sclerosis in adults. Olek MJ, et al. Treatment of acute exacerbations of multiple sclerosis in adults. Wingerchuk DM. Multiple sclerosis: Current and emerging disease-modifying therapies and treatment strategies.

Mayo Clinic Proceedings. Pizzorno JE, et al. In: Textbook of Natural Medicine. This generally happens within 10 years of the first diagnosis.

In secondary-progressive MS, people may still experience relapses. Instead, it steadily worsens. Approximately 15 percent of people are diagnosed with a relatively uncommon form of the disease, called primary-progressive MS. This form is characterized by slow and steady disease progression with no remission periods.

Some people with primary-progressive MS experience occasional plateaus in their symptoms as well as minor improvements in function that tend to be temporary. There are variations in the progression rate over time. The first stage to consider occurs before your doctor has made a diagnosis of MS. Genetic and environmental factors are thought to play a role in who gets MS.

In general, MS becomes more severe over time. Everyone with MS will experience their own timeline. For others, symptoms may become severe. Talk to your doctor about your symptoms so that they can come up with a treatment plan specific to you.

The next step on the continuum is receiving a diagnosis of MS. However, once it is better defined, raising awareness of this among a range of specialist doctors — not just neurologists, but also urologists, ophthalmologists and psychiatrists — could help to trigger the necessary tests and investigations that can identify whether or not someone has MS at an earlier stage.

With thanks to MS Research Australia — the lead provider of research summaries on our website. UK study Another recent UK study, published in the Annals of Neurology , showed that a similar range of symptoms were more common in people with MS in the 10 years prior to diagnosis. A new potential biomarker for the diagnosis of MS Diagnosis: making it early and getting it right Improving diagnosis of MS Diagnosis, monitoring and biomarkers Symptoms Pro-drome study: 5 years before onset of MS Pro-dromal symptoms of MS in primary care.

These strategies include a careful medical history, a neurologic exam and various tests including magnetic resonance imaging MRI , spinal fluid analysis , and blood tests to rule out other conditions. At this time, there are no symptoms, physical findings or laboratory tests that can — by themselves — determine if you have MS. The doctor uses several strategies to determine if you meet the MS diagnostic criteria.

In order to make a diagnosis of MS, the physician must:. The MRI can be used to look for a second area of damage in a person who has experienced only one attack also called a relapse or an exacerbation of MS-like symptoms — referred to as clinically-isolated syndrome CIS.

The MRI can also be used to confirm that damage has occurred at two different points in time. In some circumstances, the presence of oligoclonal bands in a person's cerebrospinal fluid analysis can be used instead of dissemination in time to confirm the MS diagnosis.

In many instances, medical history and neurologic exam provide enough evidence to meet the diagnostic criteria. Other tests are used to confirm the diagnosis or to identify other possible causes of the symptoms or neurological exam findings.



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