An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully.
Combining selective serotonin reuptake inhibitors SSRIs with naproxen increases your risk of stomach and intestinal bleeding. Examples of these drugs include:. Naproxen might make your blood pressure medications not work as well.
Examples of these medications include:. If you take cholestyramine with naproxen, your body may absorb naproxen more slowly than usual. That means it may take longer to work. If you take naproxen with lithium, it may increase the lithium in your body to harmful levels. Taking methotrexate with naproxen can lead to harmful levels of methotrexate in your body.
Taking warfarin with naproxen increases your risk of stomach and intestinal bleeding. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:. Too much of the drug in your body can be dangerous. Children in this age group generally receive the oral suspension form of this drug. It should be given twice per day in evenly spaced doses. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you.
Naproxen can cause high blood pressure or make your high blood pressure worse. It can also make your high blood pressure medications not work as well. You may need to watch your blood pressure level carefully while taking naproxen. Some formulations of this medication have extra salt in them. Naproxen can cause an asthma attack. If you have an allergic reaction, call your doctor or local poison control center right away.
If your symptoms are severe, call or go to the nearest emergency room. Taking it again could be fatal cause death. Naproxen may cause life threatening allergic reactions. Either can cause severe damage to your skin or internal organs and can lead to death. Naproxen can cause harm to an unborn baby if taken at 20 weeks or later in pregnancy. For people with stomach problems: If you have a history of ulcers or stomach or intestinal bleeding, naproxen increases your risk of stomach or intestinal bleeding.
If you have serious kidney disease, you should not use this drug. For pregnant women: Naproxen is a pregnancy category C drug. That means two things:. Avoid naproxen during the third trimester of pregnancy. It could harm your pregnancy.
For women who are breastfeeding: Naproxen is passed through breast milk and could cause side effects in a child who is breastfed.
Breastfeeding is not recommended while taking this medication. Your body may process this drug more slowly. Too much of the drug in your body can be harmful. Error Email field is required. Error Include a valid email address.
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Mayo Clinic does not endorse companies or products. People with serious heart conditions, such as heart disease , cerebrovascular disease , and congestive heart failure , may experience severe side effects from taking naproxen. People with high blood pressure should only take naproxen cautiously. Naproxen can cause sodium retention in the kidneys, which can result in increased blood pressure.
A person with high blood pressure should consult their doctor before taking naproxen. Gastrointestinal side effects of taking naproxen can be severe. Bleeding in the stomach, the formation of ulcers, and stomach or intestinal blockages can occur when taking naproxen.
Most often, older adults are the most vulnerable age group for gastrointestinal side effects. People who have a history of ulcers or gastrointestinal bleeding have a fold higher risk for developing a bleed when taking naproxen.
For these individuals, even short-term treatment can be risky. Naproxen may interact with several prescription and nonprescription drugs. Drinking alcohol and taking naproxen may increase the risk of gastrointestinal side effects.
People taking the antidepressant class of selective serotonin reuptake inhibitors SSRIs have an increased risk of gastrointestinal bleeding and ulcers when taking naproxen. SSRIs include:. Oral steroids, such as prednisone and antiplatelet drugs, may also increase stomach and intestinal bleeding and ulceration if people combine them with naproxen. Naproxen blocks the aggregation of platelets, which is an essential step in blood clotting.
Blocking the aggregation of platelets can increase the time it takes for bleeding to stop. People must talk to a doctor before combining naproxen with blood thinners, such as antiplatelet and anticoagulant medications.
NSAIDs can prevent the body from producing prostaglandin, which may affect pregnancy. Taking naproxen during the third trimester of pregnancy may cause heart malformations in the fetus.
Also, nursing babies may experience serious side effects if the mother is taking naproxen. Doctors do not recommend naproxen for women who are breastfeeding.
Asthma symptoms and severe allergic reactions may occur when affected individuals take aspirin. These people should avoid naproxen and all other NSAIDs because of the risk of developing severe side effects. During the first two trimesters of pregnancy, women should use naproxen cautiously.
Once the pregnancy enters the third trimester, they must avoid taking naproxen. Naproxen may be present in breast milk, which can cause serious side effects for an infant. People should not combine certain antidepressants, high blood pressure, and blood thinners with naproxen.
Certain diagnoses may increase the likelihood of experiencing side effects, such as heart disease, ulcers, and kidney disease. Children under 12 years old should avoid using naproxen unless a doctor prescribes the medication.
People can use it to relieve pain that inflammation causes. Naproxen is not safe for everyone. People taking certain medications should use naproxen cautiously to avoid side effects. People with stomach or intestinal diseases, cardiac disease, or kidney disease should discuss the use of NSAIDs with their doctor.
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